p16 Ink4a , a marker of cellular senescence, is associated with renal disease in the B6. NZMSle1/Sle2/Sle3 mouse model of lupus.

Gaëlle TilmanEmilie DupréLaura WatteyneCharlotte Anne BaertDelphine NolfFatima BenhaddiFanny LambertAurélie DaumerieCaroline BouzinSophie LucasNisha Limaye

Published in: Lupus science & medicine (2023)

kidney, and their association with renal disease severity. This provides a preclinical model in which to test for the role of cellular senescence in the pathogenesis of LN, as a potential kidney-intrinsic disease mechanism.

Keyphrases

systemic lupus erythematosus
disease activity
mouse model
dna damage
endothelial cells
rheumatoid arthritis
stress induced
stem cells
mesenchymal stem cells