Theranostic Contribution of Extracellular Matrix Metalloprotease Inducer-Paramagnetic Nanoparticles Against Acute Myocardial Infarction in a Pig Model of Coronary Ischemia-Reperfusion.

Rafael Ramirez-CarracedoMarcelo Sanmartín Fernández Amadeo Ten-Esteve Ignacio HernandezLaura TesoroJavier Diez-MataLaura BotanaKarina Ovejero-ParedesMarco FiliceÁngel Alberich-Bayarri Luis Martí-BonmatíCarlota Largo-AramburuMarta SauraJose Luis ZamoranoCarlos Zaragoza

Published in: Circulation. Cardiovascular imaging (2022)

Our data point towards NAP9 as a promising theragnostic tool in managing acute myocardial infarction, by inhibiting EMMPRIN-induced extracellular matrix degradation and allowing noninvasive visualization of cardiac necrosis progression over time.

Keyphrases

extracellular matrix
acute myocardial infarction
left ventricular
percutaneous coronary intervention
coronary artery disease
high glucose
coronary artery
diabetic rats
electronic health record
signaling pathway
photodynamic therapy
aortic stenosis
big data
heart failure
aortic valve