+3179G/A Insulin-Like Growth Factor-1 Receptor Polymorphism: A Novel Susceptibility Contributor in Anti-Ro/SSA Positive Patients with Sjögren's Syndrome: Potential Clinical and Pathogenetic Implications.

Charalampos Skarlis Nikolaos MarketosAdrianos NezosAsimina PapanikolaouMichael VoulgarelisMichael KoutsilierisHaralampos M MoutsopoulosClio P Mavragani

Published in: Journal of clinical medicine (2021)

The rs2229765 IGF1R variant confers increased susceptibility for seropositive primary SS. Dampened IGF1R mRNA and protein expression in salivary gland tissues could be related to increased apoptosis and subsequently to the activation of inflammasome pathways.

Keyphrases

binding protein
growth hormone
pi k akt
oxidative stress
cell cycle arrest
gene expression
endoplasmic reticulum stress
cell death
disease activity
human health
cell proliferation
drug induced