Cachexia causes time-dependent activation of the inflammasome in the liver.
Rodrigo Xavier das NevesAlex S YamashitaDaniela M R RiccardiJulia Köhn-GaoneRodolfo G CamargoNelson I NetoDaniela CaetanoSilvio P GomesFelipe H SantosJoanna D C C LimaMiguel L BatistaJosé Cesar Rosa-NetoPaulo Sérgio Martins De AlcântaraLinda F MaximianoJosé P OtochGiorgio TrinchieriJanina E E Tirnitz-ParkerMarilia SeelaenderPublished in: Journal of cachexia, sarcopenia and muscle (2023)
The results show that cancer cachexia is associated with an increase in the number of myeloid cells in rodent and human liver and with modulation of hepatic inflammasome pathway. The latter contributes to the aggravation of systemic inflammation, through increased release of IL-1β.