Phase 1 trial of first-line bintrafusp alfa in patients with locally advanced or persistent/recurrent/metastatic cervical cancer.

Ana Oaknin Sharad A Ghamande Yuka Kasamatsu Marta Gil-Martin Juan Francisco Grau Bejar Carmen Garcia-Duran Masashi Sato Abdul Siddiqui Surendra Pal Chaudhary Yulia Vugmeyster Kosei Hasegawa

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Bintrafusp alfa had manageable safety and demonstrated clinical activity, further supporting the investigation of TGF-β/PD-L1 inhibition in HPV-associated cancers, including cervical cancer.

Keyphrases

locally advanced
squamous cell carcinoma
replacement therapy
rectal cancer
small cell lung cancer
neoadjuvant chemotherapy
transforming growth factor
high grade
radiation therapy
phase ii study
epithelial mesenchymal transition
smoking cessation
open label
cervical cancer screening