Regulation of osteoclastogenesis by mast cell in rheumatoid arthritis.
Kyoung-Woon KimBo-Mi KimJi-Yeon WonHong-Ki MinKyung-Ann LeeSang-Heon LeeHae-Rim KimPublished in: Arthritis research & therapy (2021)
IL-33 increased inflammatory and tissue-destructive cytokines by activation of mast cells. Mast cells stimulated osteoclast differentiation in monocytes. Mast cells could stimulate osteoclastogenesis indirectly through production of tissue-destructive cytokines and directly through stimulation of osteoclast precursors.