Regulation of osteoclastogenesis by mast cell in rheumatoid arthritis.

Kyoung-Woon KimBo-Mi KimJi-Yeon WonHong-Ki MinKyung-Ann LeeSang-Heon LeeHae-Rim Kim

Published in: Arthritis research & therapy (2021)

IL-33 increased inflammatory and tissue-destructive cytokines by activation of mast cells. Mast cells stimulated osteoclast differentiation in monocytes. Mast cells could stimulate osteoclastogenesis indirectly through production of tissue-destructive cytokines and directly through stimulation of osteoclast precursors.

Keyphrases

bone loss
rheumatoid arthritis
lps induced
oxidative stress
dendritic cells
disease activity
ankylosing spondylitis
peripheral blood
systemic lupus erythematosus
inflammatory response
immune response