The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans.
Nicola L HawleyRachel L DuckhamJenna Colavincenzo CarlsonTake NaseriMuagututia Sefuiva ReupenaViali LamekoAlysa PomerAbigail WetzelMelania SeluVaimoana LupematisilaFolla UnasaLupesina VesiTracy FatuSeipepa UnasaKima Faasalele-SavusaAnna C RivaraEmily RussellJames P DelanySatupaitea VialiErin E KershawRyan L MinsterDaniel E WeeksStephen T McGarveyPublished in: Obesity (Silver Spring, Md.) (2022)
The protective effect of rs373863828 in CREBRF, common among Pacific Islanders, on type 2 diabetes does not operate through body composition. Rather, the variant's effects on body size/composition and fasting glucose likely operate via different, tissue-specific mechanisms.