Microstructural Mapping of Neural Pathways in Alzheimer's Disease using Macrostructure-Informed Normative Tractometry.

Yixue FengBramsh Q ChandioJulio E Villalon-ReinaSophia I Thomopoulos Talia M NirSebastian BenavidezEmily LaltooTamoghna ChattopadhyayHimanshu JoshiGanesan VenkatasubramanianJohn P JohnNeda Jahanshad Robert I Reid Clifford R JackMichael W WeinerPaul M Thompsonnull null

Published in: bioRxiv : the preprint server for biology (2024)

We show that MINT, by jointly modeling tract shape and microstructure, has potential to disentangle and better interpret the effects of degenerative disease on the brain's neural pathways.

Keyphrases

white matter
high resolution
cognitive decline
resting state
risk assessment
brain injury
functional connectivity
cerebral ischemia