Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.

He Li Saumya Dushyant Sisoudiya Bailey A Martin-Giacalone Michael M Khayat Shannon DuganDeborah A Marquez-DoMichael E ScheurerDonna MuznyEric BoerwinkleRichard A GibbsYueh-Yun ChiDonald A BarkauskasTammy LoDavid C HallDouglas R StewartJoshua D SchiffmanStephen X SkapekDouglas S Hawkins Sharon E Plon Aniko Sabo Philip J Lupo

Published in: Journal of the National Cancer Institute (2022)

These findings demonstrate that genetic risk of RMS results from germline predisposition variants associated with a wide spectrum of cancer susceptibility syndromes. Germline genetic testing for children with RMS should be informed by RMS subtypes and not be limited to only young patients.

Keyphrases

papillary thyroid
copy number
dna repair
end stage renal disease
young adults
squamous cell
ejection fraction
chronic kidney disease
prognostic factors
lymph node metastasis
squamous cell carcinoma
gene expression
patient reported outcomes
oxidative stress