Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview.
Nidhi ChauhanAlfred Chin-Yen TayBarry J MarshallUtkarsh JainPublished in: Helicobacter (2018)
This review describes an overview of how VacA is secreted by H. pylori and contributes to colonization and virulence in multiple ways by affecting epithelial cells, T cells, Dendritic cells, B cells, and Macrophages. The reported evidence suggests that the comprehensive outlook need to be developed for understanding distinctive functionalities of VacA.
Keyphrases
- helicobacter pylori
- dendritic cells
- escherichia coli
- induced apoptosis
- helicobacter pylori infection
- cell cycle arrest
- pseudomonas aeruginosa
- immune response
- staphylococcus aureus
- biofilm formation
- regulatory t cells
- antimicrobial resistance
- signaling pathway
- endoplasmic reticulum stress
- cell death
- oxidative stress
- cystic fibrosis
- candida albicans