Association between Galectin-3 levels within central and peripheral venous blood, and adverse left ventricular remodelling after first acute myocardial infarction.
Olivera M AndrejicRada M VučićMilan PavlovicLana McClementsDragana StokanovicTatjana Jevtovic-StoimenovValentina N NikolicPublished in: Scientific reports (2019)
Our study investigates association between Galectin-3 levels and adverse left ventricular remodelling (LVR) at six months. Fifty-seven patients following first acute myocardial infarction (AMI) were enrolled in this study and blood samples collected on day 1 from the femoral vein and artery, the right atrium near the coronary sinus and the aortic root, and on day 30, from the cubital vein. Patients with LVESV ≥20% at six months, were included in the LVR group. On day 1, Galectin-3 plasma levels in the femoral vein (10.34 ng/ml ± 3.81 vs 8.22 ng/ml ± 2.34, p = 0.01), and near coronary sinus (10.7 ng/ml ± 3.97 vs 8.41 ng/ml ± 2.56, p = 0.007) were higher in the LVR group. Positive correlations between Galectin-3 levels from aortic root and coronary sinus, aortic root and femoral vein, and coronary sinus and femoral vein, were observed in both groups. On day 30, Galectin-3 concentration in the cubital vein was an independent risk factor of LVR six months post-AMI, demonstrating 1.5-fold increased risk. Day-30 Galectin-3 also showed positive correlations with echocardiography parameters indicative of diastolic and systolic dysfunction. Determining Galectin-3 plasma concentration on day 30 following AMI could have beneficial prognostic value in predicting LVR.
Keyphrases
- left ventricular
- acute myocardial infarction
- aortic stenosis
- hypertrophic cardiomyopathy
- coronary artery disease
- coronary artery
- cardiac resynchronization therapy
- heart failure
- left atrial
- mitral valve
- percutaneous coronary intervention
- ejection fraction
- aortic valve
- pulmonary artery
- blood pressure
- emergency department
- risk factors
- newly diagnosed
- end stage renal disease
- acute coronary syndrome
- pulmonary hypertension
- pulmonary embolism
- electronic health record
- pulmonary arterial hypertension
- computed tomography
- transcatheter aortic valve replacement
- aortic dissection
- peritoneal dialysis