Apolipoprotein E moderates the association between non-APOE polygenic risk score for Alzheimer's disease and aging on preclinical cognitive function.

Yuexuan XuZhongxuan SunErin JonaitisYuetiva DemingQiongshi LuSterling C JohnsonCorinne D Engelman

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

). The adverse genetic effect caused by the combined effect of the currently known genetic variants is more detrimental among APOE ε4 carriers around age 70. Individuals who are APOE ε4 carriers with high PRSs are the most vulnerable to the harmful effects caused by genetic burden.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
genome wide
copy number
stem cells
type diabetes
emergency department
cell therapy
risk factors
bone marrow
adverse drug
drug induced