SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation.

Fei LiuChristopher D CoxReshmi ChowdhuryLaura DovekHuytram NguyenTie LiSichen LiByram OzerArthur ChouNhung NguyenBowen WeiJoseph AntoniosHoracio SotoHarley KornblumLinda LiauRobert PrinsP Leia NghiemphuWilliam YongTimothy CloughesyAlbert Lai

Published in: Journal of neuro-oncology (2019)

We defined a previously under-recognized group of coordinately methylated CpG islands common to both IDH1WT and IDH1MUT gliomas (GT-CMG). Within GT-CMG, we identified SPINT2 as a top cancer-related candidate and demonstrated that SPINT2 suppressed GBM via down-regulation of c-Met activation.

Keyphrases

wild type
tyrosine kinase
high grade
dna methylation
low grade