Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells.
Junwan LuYujie LiShiwei GongJiaxin WangXiaoang LuQiumei JinLili YuQin ChenPublished in: Cell communication and signaling : CCS (2022)
Our study revealed that CPX targets cellular bioenergetics and activates unfolded protein response in ER to drive apoptosis in NSCLC cells, indicating that CPX may be a potential therapeutic drug for the treatment of NSCLC. Video Abstract.
Keyphrases
- cell cycle arrest
- endoplasmic reticulum stress
- induced apoptosis
- cell death
- small cell lung cancer
- pi k akt
- oxidative stress
- single cell
- advanced non small cell lung cancer
- endoplasmic reticulum
- stem cells
- protein protein
- amino acid
- small molecule
- mesenchymal stem cells
- estrogen receptor
- binding protein
- epidermal growth factor receptor
- electronic health record