Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries.

Olivia LenoirFrançois GaillardHélène LazarethBlaise RobinPierre-Louis Tharaux

Published in: Journal of diabetes research (2017)

Genetic Hmox1 partial deficiency is sufficient to sensitize mice to the development of diabetic glomerular microvascular lesions. HO-1 exerts antioxidant effects in the kidney during diabetes mellitus. These have protective effects on the development of glomerular endothelial injury.

Keyphrases

diabetic nephropathy
type diabetes
high glucose
high fat diet induced
endothelial cells
wound healing
oxidative stress
genome wide
gene expression
dna methylation
anti inflammatory
metabolic syndrome
cell proliferation