Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study.
Jarkko S HeiskanenJussi A HernesniemiSaku RuohonenNina Hutri-KähönenMika KÄhÖnenEero JokinenPäivi TossavainenMerja KallioTomi LaitinenTerho LehtimäkiJorma ViikariMarkus JuonalaJaakko NevalainenOlli T RaitakariPublished in: Annals of medicine (2021)
High BMI in early-life confers a sustained effect on LVM and the risk for eccentric hypertrophy independently of adulthood risk factors. KEY MESSAGES Excess in BMI in early-life has an independent effect on LVM and the risk of developing eccentric hypertrophy regardless of overweight status in adulthood. Systolic blood pressure levels in early-life did not have an independent effect on LVM or LV remodeling. The clinical implication of this study is that primary prevention of obesity in early-life may prevent the development of high LVM and eccentric hypertrophy.
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