Toward an Objective Diagnostic Test for Bacterial Cellulitis.

Daniel J PallinLynn BryRichard C DwyerAdam D LipworthDonald Y LeungCarlos A CamargoThomas S KupperMichael R FilbinGeorge F Murphy

Published in: PloS one (2016)

Most "cellulitis" patients had microbiologically-negative biopsies. Procalcitonin was undetectable, and HLA-DQA1 elevated, in confirmed bacterial cases. Multivariable transcriptomic profiling results supported our algorithm's ability to identify patients with true bacterial cellulitis. A larger sample may allow discovery of an immunological signature capable of distinguishing bacterial cellulitis from its mimics in clinical practice.

Keyphrases

end stage renal disease
clinical practice
single cell
newly diagnosed
chronic kidney disease
machine learning
small molecule
peritoneal dialysis
prognostic factors
rna seq
patient reported outcomes