An Improved Method for Estimating Nephron Number and Association of the Resulting Nephron Number Estimates with Chronic Kidney Disease Outcomes.

Aleksandar DenicAidan F MullanMariam P AlexanderLuke D WilsonJoshua AugustineAnthony C LuehrsMark D StegallTimothy L KlineVidit SharmaR Houston ThompsonAndrew D Rule

Published in: Journal of the American Society of Nephrology : JASN (2023)

Compared with an older method for estimating nephron number, a new method that addresses several sources of bias results in nephron number estimates than are 27% higher in donors and 1% higher in tumor patients and show consistency between two populations. Low nephron number independently predicts CKD in both populations.

Keyphrases

chronic kidney disease
end stage renal disease
peritoneal dialysis
newly diagnosed
type diabetes
physical activity
prognostic factors
metabolic syndrome
drinking water
adipose tissue
genetic diversity
skeletal muscle
glycemic control
patient reported