Three novel structural variations at the major histocompatibility complex and IL12B predispose to psoriasis.
Q ZhenY ZhangY YuH YangT ZhangX LiX MoB LiJ WuY LiangH GeQ XuWeiwei ChenWenjun QianH XuGang ChenB BaiJ ZhangYan LuS ChenH ZhangY ZhangX ChenXin LiX JinX LinL YongM FangJ ZhaoY LuS WuD JiangJ ShiH CaoY QiuS LiX KangJ ShenH MaS SunYi-Ming FanW ChenM BaiQ JiangWeiyang LiC LvS LiM ChenF LiY LiLiangdan SunPublished in: The British journal of dermatology (2021)
We have constructed the most comprehensive SV map for psoriasis thus far and enriched the genetic architecture and pathogenesis of psoriasis, and highlight the non-negligible impact of SVs on complex diseases.