Effect of co-medications and potential risk factors of high-dose methotrexate-mediated acute hepatotoxicity in patients with osteosarcoma.
Sheng-Fan WangKuan-Wei HuangYueh-Ching ChouHsin-Chen LeePo-Kuei WuWei-Ming ChenGiun-Yi HungYuh-Lih ChangPublished in: Cancer medicine (2023)
Co-administration of PPIs, TMP-SMX, or NSAIDs may have limited effects on acute hepatotoxicity in well-monitored and adequately pre-medicated patients with OGS undergoing chemotherapy with HD-MTX. Clinicians should pay particular attention to ALT levels when prescribing HD-MTX to children and women.
Keyphrases
- high dose
- drug induced
- liver failure
- risk factors
- respiratory failure
- primary care
- polycystic ovary syndrome
- aortic dissection
- stem cell transplantation
- young adults
- health insurance
- working memory
- adverse drug
- hepatitis b virus
- palliative care
- pregnant women
- emergency department
- pregnancy outcomes
- extracorporeal membrane oxygenation
- radiation therapy
- cervical cancer screening
- breast cancer risk
- skeletal muscle
- climate change
- intensive care unit