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A comparison of two methods for the detection of circulating tumour cells in patients with oral cavity cancer.

Justin CurtinGordon WongWeilan WangPeter J ThomsonAlfred King-Yin LamSiu-Wai Choi
Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)
These results highlight significant differences in detection of CTCs, CTM and CTECs between i-FISH and microfiltration when applied to OSCC samples, suggesting that technologies capable of detecting circulating aneuploid cells more accurately detect CTCs. i-FISH also detected CTM and CTEC not detected using ISET® . With proven prognostic relevance in adenocarcinomas, accurate enumeration of CTCs, CTMs and CTECs may be a clinically useful tool in the management of OSCC and may aid in the reduction of false-negative diagnoses.
Keyphrases
  • circulating tumor cells
  • induced apoptosis
  • cell cycle arrest
  • label free
  • real time pcr
  • squamous cell carcinoma
  • squamous cell
  • papillary thyroid
  • young adults