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IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species.

Marcus Ho-Yin WongEdward Wai-Chi ChanLiqi XieRuichao LiSheng Chen
Published in: Antimicrobial agents and chemotherapy (2016)
This study reported and analyzed the complete sequences of two oqxAB-bearing IncHI2 plasmids harbored by a clinical Salmonella enterica serovar Typhimurium strain and an S Indiana strain of animal origin, respectively. In particular, pA3T recovered from S Indiana comprised the resistance determinants oqxAB, aac(6')Ib-cr, fosA3, and blaCTX-M-14 Further genetic screening of 63 oqxAB-positive Salmonella isolates revealed that the majority carried IncHI2 plasmids, confirming that such plasmids play a pivotal role in dissemination of oqxAB in Salmonella spp.
Keyphrases
  • escherichia coli
  • listeria monocytogenes
  • klebsiella pneumoniae
  • genetic diversity
  • multidrug resistant
  • genome wide
  • single cell
  • gene therapy