CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease.

Noëlle WarmenhovenGonzalo Sánchez-BenavidesArmand González-EscalanteMarta Milà-AlomàMahnaz ShekariDavid López-MartosPaula Ortiz-RomeroGwendlyn KollmorgenClara Quijano-RubioCarolina MinguillónJuan Domingo GispertNatalia Vilor-TejedorEider Arenaza-UrquijoEleni PalpatzisNicholas J AshtonHenrik ZetterbergKaj BlennowMarc Suárez-CalvetOriol Grau-Riveranull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Higher cerebrospinal fluid (CSF) soluble triggering receptor expressed on myeloid cell 2 (sTREM2) relates to better longitudinal cognitive performance. The association between CSF sTREM2 and cognition is independent of Alzheimer's disease (AD) pathology. Targeting microglial reactivity may be a therapeutic strategy for AD prevention.

Keyphrases

cerebrospinal fluid
cognitive decline
mild cognitive impairment
neuropathic pain
white matter
single cell
lipopolysaccharide induced
stem cells
mesenchymal stem cells
multiple sclerosis
spinal cord