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Trajectory of inhaled cadmium ultrafine particles in smokers.

Einat Fireman-KleinIlan KleinOmer EphratYoram DekelAharon KesselYochai Adir
Published in: BMJ open respiratory research (2021)
Smokers had elevated UFP and cadmium content in urine compared with non-smokers (4.6 E8/mL and 20.6 ppm vs 3.4 E8/mL and 18.5 ppm, p=0.05 and p=0.05, respectively). Smokers had elevated levels of lead and rubidium compared with non-smokers (8.9 ppm and 27 ppm vs 7.8 ppm and 2 ppm, p=0.05 and p=0.04, respectively) DISCUSSION: We suggest that the trajectory of cadmium-related UFP in smokers begins by its inhalation into the airways. The UFPs induce inflammation and oxidative stress in the small airways, are subsequently translocated from the interstitium to the circulation and are finally detected and secreted in urine.
Keyphrases
  • smoking cessation
  • oxidative stress
  • cystic fibrosis
  • dna damage
  • ischemia reperfusion injury
  • particulate matter
  • heat shock