Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival.

Galateja JordakievaRoswitha M Budge-WolframAlexandra C BudinskyMariam NikfardjamGeorg Delle-KarthAngelika GirardJasminka Godnic-CvarRichard CrevennaGottfried Heinz

Published in: Wiener klinische Wochenschrift (2020)

The MMP‑9 and TIMP‑1 levels are significantly elevated in acute critical care settings with increased short-term mortality risk, especially in patients with underlying heart disease. These findings support the value of MMPs and TIMPs as prognostic markers and potential therapeutic targets in conditions leading to systemic inflammation and acute organ failure.

Keyphrases

liver failure
respiratory failure
drug induced
aortic dissection
emergency department
intensive care unit
cell migration
mechanical ventilation
pulmonary hypertension
hepatitis b virus
risk assessment