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The value of the post-thaw CD34+ count with and without DMSO removal in the setting of autologous stem cell transplantation.

Nicolai RohnerJakob R PasswegDimitrios A TsakirisJörg P HalterDominik HeimAndreas S BuserLaura InfantiAndreas Holbro
Published in: Transfusion (2018)
DMSO removal was associated with delayed platelet and RBC engraftment without preventing adverse events. CD34+ cell enumeration after thawing remains difficult to perform, but grafts showing higher cell loss during cryopreservation and thawing are associated with slower engraftment. Prospective studies on the role of DMSO removal and postthaw CD34+ enumeration using defined protocols are needed.
Keyphrases
  • stem cell transplantation
  • cell therapy
  • single cell
  • high dose
  • bone marrow
  • stem cells
  • low dose
  • peripheral blood