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TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc.

Garrett W D EassonAlireza SavadipourChristian E GonzalezFarshid GuilakSimon Y Tang
Published in: JOR spine (2023)
We demonstrated that TRPV4 critically mediates the cytokine production following dynamic and static loading. The activation of TRPV4 upregulated a diverse set of cytokines that may suppress the chemotaxis of T-cells and monocytes, implicating the role of TRPV4 in maintaining the immune privilege of healthy IVD.
Keyphrases
  • neuropathic pain