Login / Signup

An amine template strategy to construct successive C-C bonds: synthesis of benzo[ h ]quinolines by a deaminative ring contraction cascade.

Timothy Patrick McFaddenChideraa Iheanyi NwachukwuAndrew George Roberts
Published in: Organic & biomolecular chemistry (2022)
We developed a convergent strategy to build, cyclize and excise nitrogen from tertiary amines for the synthesis of polyheterocyclic aromatics. Biaryl-linked azepine intermediates can undergo a deaminative ring contraction cascade reaction, excising nitrogen with the formation of an aromatic core. This strategy and deaminative ring contraction reaction are useful for the synthesis of benzo[ h ]quinolines.
Keyphrases
  • smooth muscle
  • amino acid
  • mass spectrometry
  • simultaneous determination
  • solid phase extraction