Cadmium induces mitophagy via AMP-activated protein kinases activation in a PINK1/Parkin-dependent manner in PC12 cells.

Tao WangQiaoping ZhuBinbin CaoYan YuanShuangquan WenZongping Liu

Published in: Cell proliferation (2020)

These results suggest that Cd induces mitophagy via the PINK/Parkin pathway following AMPK activation in PC12 cells. Targeting the balanced activity of AMPK/PINK1/Parkin-mediated mitophagy signalling may be a potential therapeutic approach to treat Cd-induced neurotoxicity.

Keyphrases

protein kinase
nlrp inflammasome
skeletal muscle
high glucose
diabetic rats
heavy metals
cancer therapy
drug induced
oxidative stress
binding protein
small molecule