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The Outcome of Porcine Foetal Infection with Bungowannah Virus is Dependent on the Stage of Gestation at Which Infection Occurs. Part 1: Serology and Virology.

Deborah S FinlaisonPeter D Kirkland
Published in: Viruses (2020)
Bungowannah virus is a novel porcine pestivirus identified in a disease outbreak in Australia in 2003. The aim of this study was to determine the outcome of infection of the pregnant pig with this virus. Twenty-four pregnant pigs were infected at days 35, 55, 75 or 90 of gestation. Blood, tonsillar and rectal swabs were collected from each pig at birth and then weekly until euthanasia or death. Tissues were sampled at necropsy. Viral load was measured by real-time reverse-transcription polymerase chain reaction (qRT-PCR) and antibody levels in serum by peroxidase-linked immunoassay. Bungowannah virus was detected in the serum and excretions of all infected pigs at birth regardless of the stage of gestation at which infection occurred. Persistent infections occurred following infection prior to the development of foetal immunocompetence. Unexpectedly some animals infected at day 55 of gestation later cleared the virus and seroconverted. Viraemia and viral shedding resolved quickest following infection in late gestation.
Keyphrases
  • gestational age
  • preterm infants
  • gene expression
  • pregnant women
  • sars cov
  • hydrogen peroxide