Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes.
Renata SaucedoAldo Ferreira-HermosilloMagalhi Robledo-ClementeMary Flor Díaz-VelázquezJorge ValenciaPublished in: Metabolites (2024)
Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.
Keyphrases
- dna methylation
- type diabetes
- metabolic syndrome
- cardiovascular disease
- insulin resistance
- gestational age
- birth weight
- early life
- weight gain
- gene expression
- high fat diet
- healthcare
- genome wide
- mental health
- adipose tissue
- health information
- body mass index
- physical activity
- coronary artery disease
- climate change
- preterm birth
- combination therapy
- high fat diet induced
- social media
- nk cells