Overcoming hypoxia-induced functional suppression of NK cells.

Kristen SolocinskiMichelle R PadgetKellsye P FabianBenjamin WolfsonFabiola CecchiTodd HembroughStephen C BenzShahrooz RabizadehPatrick Soon-ShiongJeffrey Schlom James W Hodge

Published in: Journal for immunotherapy of cancer (2021)

In contrast to HD NK cells, haNK cells are resistant to acute hypoxia. The potent cytolytic function of haNK cells was maintained in an environment comparable to what would be encountered in a tumor. The data presented here provide an additional mechanism of action for haNK cells that are currently being evaluated in clinical trials for several tumor types.

Keyphrases

induced apoptosis
nk cells
clinical trial
cell cycle arrest
endoplasmic reticulum stress
cell death
magnetic resonance imaging
computed tomography
endothelial cells
respiratory failure
study protocol
open label
hepatitis b virus
double blind