Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia.
Yanfang LiuTianyuan ZhangXing ZouZhongwen YuanYufeng LiJiankun ZangNiu HeLizhen HeLiangxue LaiDan LuPublished in: Stroke and vascular neurology (2023)
In conclusion, our results suggest that PLGA-PAMAM@CircOGDH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons; therefore, our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.
Keyphrases
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- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- cell death
- spinal cord
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- cerebral ischemia
- drug release
- high fat diet induced
- skeletal muscle
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- oxide nanoparticles
- hyaluronic acid
- functional connectivity
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- spinal cord injury
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- cell proliferation
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