Imaging glymphatic response to glioblastoma.
Jasleen KaurGuangliang DingLi ZhangYong LuHao LuoLian LiEdward BoydQingjiang LiMin WeiZhenggang ZhangMichael ChoppQuan JiangPublished in: Cancer imaging : the official publication of the International Cancer Imaging Society (2023)
Our study demonstrates the presence of GBM-impaired glymphatic response in the rat brain and impaired perineural pathway along the optic nerves. Reduced glymphatic waste clearance may lead to the accumulation of toxic waste solutes and pro-inflammatory signaling molecules which may affect the progression of the GBM.