Fluorescent- and tagged-protoxin II peptides: potent markers of the Nav 1.7 channel pain target.
Jérôme MontnachStephan De WaardSébastien NicolasSophie BurelNancy OsorioClaude ZoukimianMassimo MantegazzaRachid BoukaibaRémy BéroudMichel PartisetiPatrick DelmasCéline MarionneauMichel De WaardPublished in: British journal of pharmacology (2021)
The properties of these ProTx II analogues as tools for Nav channel purification and cell distribution studies pave the way for a better understanding of ProTx II channel receptors in pain and their pathophysiological implications in sensory neuronal processing. The new fluorescent ProTx II should also be useful in the design of new drug screening strategies.