The impact of ADRB2 polymorphisms on immune responses and norepinephrine-induced immunosuppression.

Roeland F StolkNiklas BruseRob Ter HorstAron JansenIsis Ricaño PonceJelle GerretsenJohannes van der HoevenVinod KumarMihai G NeteaPeter PickkersMatthijs Kox

Published in: Journal of leukocyte biology (2023)

Common nonsynonymous variants in the ADRB2 gene influence neither ex vivo cytokine production or norepinephrine-mediated immunosuppression nor the systemic in vivo inflammatory response induced by lipopolysaccharide administration in healthy volunteers.

Keyphrases

inflammatory response
immune response
toll like receptor
copy number
lps induced
lipopolysaccharide induced
high glucose
diabetic rats
drug induced
genome wide
dendritic cells
gene expression
dna methylation
endothelial cells
oxidative stress