Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks.
Carla Alessandra Scorza BahiValeria de Cassia GoncalvesFinsterer JosefFúlvio ScorzaFernando Luiz Affonso FonsecaPublished in: Cells (2024)
Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis' properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis' role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.
Keyphrases
- oxidative stress
- dna damage
- immune response
- public health
- healthcare
- mental health
- ischemia reperfusion injury
- diabetic rats
- traumatic brain injury
- dna methylation
- gene expression
- high resolution
- health information
- human health
- dendritic cells
- high throughput
- current status
- heat stress
- middle aged
- high density
- inflammatory response
- endoplasmic reticulum stress