Therapeutic Effects of Live Lactobacillus plantarum GKD7 in a Rat Model of Knee Osteoarthritis.
Yen-You LinSunny Li-Yun ChangShan-Chi LiuDavid AchudhanYou-Shan TsaiShih-Wei LinYen-Lien ChenChin-Chu ChenJun-Way ChangYi-Chin FongSung-Lin HuChih-Hsin TangPublished in: Nutrients (2022)
Osteoarthritis (OA) is a painful, progressive chronic inflammatory disease marked by cartilage destruction. Certain synovial inflammatory cytokines, such as IL-1β and TNF-α, promote OA inflammation and pain. Lactobacillus spp. is a well-known probiotic with anti-inflammatory, analgesic, antioxidant, and antiosteoporotic properties. This study evaluated the therapeutic effects of a live L. plantarum strain (GKD7) in the anterior cruciate ligament transection (ACLT)-induced OA rat model. The results show that oral administration of live L. plantarum GKD7 improved weight-bearing asymmetry after ACLT surgery. Moreover, micro-computed tomography images and histopathological analysis show that oral live L. plantarum GKD7 improved subchondral bone architecture, protected articular cartilage against ACLT-induced damage, and reduced synovial inflammation. L. plantarum GKD7 also reduced IL-1β and TNF-α production in OA cartilage and synovium. Thus, orally administered live L. plantarum GKD7 appears to effectively slow the progression of OA.
Keyphrases
- knee osteoarthritis
- oxidative stress
- anti inflammatory
- diabetic rats
- computed tomography
- rheumatoid arthritis
- high glucose
- minimally invasive
- chronic pain
- anterior cruciate ligament
- body mass index
- multiple sclerosis
- deep learning
- magnetic resonance imaging
- endothelial cells
- pain management
- extracellular matrix
- positron emission tomography
- physical activity
- machine learning
- bone mineral density
- acute coronary syndrome
- stress induced
- bone loss