Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study.
Ingrid Anne LieSezgi KaçarKristin WesnesIman BrouwerSilje S KvistadStig WergelandTrygve HolmøyRune MidgardAlla BruAstrid EdlandRandi EikelandSonia GosalHanne F HarboGrethe KlevelandYvonne S SørenesNina ØksendalKristin N VarhaugChristian A VedelerFrederik BarkhofCharlotte E TeunissenLars BøØivind TorkildsenKjell-Morten MyhrHugo VrenkenPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.