Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding.

Prabha SiddarthAlison C BurggrenDavid A MerrillLinda M ErcoliZanjbeel MahmoodJorge R BarrioGary W Small

Published in: PloS one (2018)

This is the first report to demonstrate a significant association between longer TOMM40 poly-T lengths and higher medial temporal plaque and tangle burden in non-demented older adults. Identifying biomarkers that are risk factors for AD will enhance our ability to identify subjects likely to benefit from novel AD treatments.

Keyphrases

physical activity
computed tomography
coronary artery disease
copy number
pet ct
positron emission tomography
cerebrospinal fluid
pet imaging
binding protein