Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation.

Sylvain GarciazLia N'guyen DasiPascal FinettiChristine ChevalierJulien VernereyMathilde PoplineauNadine PlatetStéphane AudebertMatthieu PophillatLuc CamoinFrançois BertucciBoris CalmelsChristian RécherDaniel BirnbaumChristian ChabannonNorbert VeyEstelle Duprez

Published in: Clinical epigenetics (2019)

Our data suggest that NPM1mut AML prognosis depends on the epigenetic silencing of the HIST1 cluster and that, among the H3K27me3 silenced histone genes, HIST1H1D plays a role in AML blast differentiation.

Keyphrases

acute myeloid leukemia
dna methylation
genome wide
allogeneic hematopoietic stem cell transplantation
gene expression
electronic health record
big data
machine learning
genome wide identification
deep learning
artificial intelligence
acute lymphoblastic leukemia
genome wide association study