ADAM10 modulates calcitriol-regulated RAGE in cardiomyocytes.

Ting-Wei LeeYu-Hsun KaoTing-I LeeYi-Jen Chen

Published in: European journal of clinical investigation (2017)

We showed that RAGE downregulation and increased sRAGE production by calcitriol were mediated through ADAM10 activation in cardiomyocytes. The results suggest that calcitriol has therapeutic potential in treating RAGE-mediated cardiovascular complications.

Keyphrases

cell proliferation
signaling pathway
risk factors
high glucose