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Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients.

Ryosuke NakamuraNoriaki ArakawaYoichi TanakaNahoko UchiyamaAkihiro SekineYoichi MashimoKeiji TsujiTatehiro KagawaKen SatoMasaaki WatanabeMitsuhiko AisoYoichi HiasaYoshiyuki TakeiHiromasa OhiraMinoru AyadaEri TsukagoshiKeiko MaekawaMasahiro TohkinYoshiro SaitoHajime Takikawa
Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)
HLA-B*35:01 is a genetic risk factor and a potential predictive biomarker for Kampo-induced DILI in the Japanese population.
Keyphrases
  • drug induced
  • risk factors
  • high glucose
  • diabetic rats
  • genome wide
  • endothelial cells
  • emergency department
  • oxidative stress
  • adverse drug
  • risk assessment
  • dna methylation
  • climate change
  • stress induced