Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID.
Nicholas A ScottLaurence PearmainSean B KnightOliver BrandDavid J MorganChristopher JaggerSarah HarbachSaba KhanHalima A ShuwaMiriam FranklinVerena KästeleThomas WilliamsIan PriseFlora A McClurePamela HackneyLara SmithMadhvi MenonJoanne E KonkelCriag LawlessJames WilsonAleaxander G MathioudakisStefan C StanelAndrew UstianowskiGabriella LindergardSeema BrijNawar Diar BakerlyPaul DarkChristopher BrightlingPilar Rivera-OrtegaGraham M LordAlex Robert Horsleynull nullKaren Piper HanleyTimothy FeltonAngela SimpsonJohn R GraingerTracy HussellElizabeth R MannPublished in: The European respiratory journal (2023)
Our data define unique monocyte signatures that define subgroups of long COVID patients, indicating a key role for monocyte migration in COVID-19 pathophysiology. Targeting these pathways may provide novel therapeutic opportunities in COVID-19 patients with persistent morbidity.