The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida.
Mihaya KotajimaJae-Hoon ChoiTomohiro SuzukiJing WuHirofumi HiraiDavid C NelsonHitoshi OuchiMakoto InaiHideo DohraHirokazu KawagishiPublished in: Bioscience, biotechnology, and biochemistry (2023)
2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-forming Lepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.
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