Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.

Jason K CullenPei-Yi YapBlake FergusonZara C BruceMotoko KoyamaHerlina HandokoKevin HendrawanJacinta L SimmonsKelly M BrooksJenny JohnsEmily S WilsonMarjorie M A de SouzaNatasa BroitPraphaporn StewartDaniel ShelleyTracey McMahonSteven M OgbourneTam Hong NguyenYi Chieh LimAlberto PaganiGiovanni AppendinoVictoria A GordonPaul W ReddellGlen M BoylePeter G Parsons

Published in: Journal for immunotherapy of cancer (2024)

These data demonstrate that TT is an oncolytic small molecule with multiple targets and confirms that cell death induced by this compound has the potential to augment antitumor responses to immunotherapy.

Keyphrases

small molecule
cell death
protein protein
cell cycle arrest
electronic health record
big data
signaling pathway
climate change