Germline Cancer Testing in Unselected Patients with Gastric and Esophageal Cancers: A Multi-center Prospective Study.

P L S UsonK L KunzeM A GolafsharG BotrusD Riegert-JohnsonL BoardmanM J BoradD AhnM B SonbolA KahnM KlintE D EsplinR L NussbaumA K StewartT Bekaii-SaabN Jewel Samadder

Published in: Digestive diseases and sciences (2022)

Universal multi-gene panel testing in gastric and esophageal cancers was associated with detection of heritable mutations in 15% of patients. The majority of PGV would not be detected with current screening guidelines and are related to DNA damage response.

Keyphrases

dna damage response
end stage renal disease
dna repair
newly diagnosed
ejection fraction
papillary thyroid
peritoneal dialysis
clinical practice
childhood cancer
squamous cell
oxidative stress
young adults
transcription factor
lymph node metastasis
genome wide identification
loop mediated isothermal amplification