Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum.
Yin-Ping SongZhen-Zhen ShiFeng-Ping MiaoSheng-Tao FangXiu-Li YinNai-Yun JiPublished in: Organic letters (2018)
Tricholumin A (1) with an unprecedented carbon skeleton was isolated from the fungus Trichoderma asperellum cf44-2, an endophyte from the marine brown alga Sargassum sp. Its structure and relative configuration were identified by extensive 1D/2D NMR and mass spectrometric data, and the absolute configuration was assigned by X-ray diffraction and ECD calculations. Compound 1 represents a highly transformed ergosterol derivative, and it exhibited inhibition of some pathogenic microbes and marine phytoplankton species.
Keyphrases
- high resolution
- cystic fibrosis
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- molecular dynamics
- electron microscopy
- density functional theory
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- machine learning
- magnetic resonance imaging
- crystal structure
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- deep learning