Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia.
Angelo M JamerlanKyu Hwan ShimYoung Chul YounCharlotte TeunissenSeong Soo Alexander AnPhilip ScheltensSangYun KimPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Only MDS showed a significant increase in o-TDP-43 concentrations in the plasma of patients with SD compared to other neurodegenerative disorders and normal controls (p < 0.05). Based on these results, o-TDP-43 concentrations through the application of MDS may be a useful plasma biomarker in SD-FTD (frontotemporal dementia) diagnosis.