Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway.

Yang LiuLanxi ZhangJie ZhaoRuilong LuXuejie ShaoKexin XuJian-Sheng LiYange Tian

Published in: International journal of chronic obstructive pulmonary disease (2024)

These results indicate that ECC-BYF III exerts a strong effective therapeutic effect against cigarette smoke combined with bacteria-induced COPD in rats by activating the Pkm2/Nrf2 signaling pathway and restoring mitochondrial oxidative stress. Although more in vivo animal model research is needed to confirm these findings, this study contributes new data to support the conventional usage of ECC-BYF III.

Keyphrases

oxidative stress
signaling pathway
diabetic rats
chronic obstructive pulmonary disease
induced apoptosis
dna damage
ischemia reperfusion injury
lung function
pi k akt
epithelial mesenchymal transition
high glucose
cystic fibrosis
human milk
machine learning
drug induced